Shared Resources

Shared Resources provide access to technologies, services and consultation that facilitate scientific interaction and enhance scientific productivity. These resources support the research efforts of the Fred Hutchinson/University of Washington Cancer Consortium, providing services that advance cancer research. For information on an individual resource and a complete description of services, expand the individual resource below.

View our core ‘Quick Reference List’ which contains a list of all of the cores, services and contact information.

Animal BioImaging Core (ABIC)

ABIC provides state of the art animal imaging equipment, including magnetic resonance imaging (MRI), micro positron emission tomography (PET), ultrasound, optical imaging, SPECT/gamma camera, and microcomputed tomography (CT) to support the wide range of scientific projects within the Fred Hutchinson/University of Washington Cancer Consortium. A hallmark of successful interdisplinary imaging research is the assemblage of investigators from diverse backgrounds around promising imaging technologies, with further development of new scientific tools and novel applications of older technologies, to achieve effective shared resource and research objectives.

Locations:
University of Washington Health Sciences
University of Washington South Lake Union
Fred Hutchinson Cancer Research Center

Director:
Satoshi Minoshima, MD, PhD

For additional information:
http://www.rad.washington.edu/research/our-research/centers/abic

Antibody Development

Antibody Development provides Consortium investigators with custom designed monoclonal and recombinant (scFv) antibodies. Intact monoclonal antibodies are produced via traditional hybridoma technology while recombinant antibodies are produced via phase display technology. Use of both of these technologies has permitted the identification of antibodies useful for traditional biochemical, cell biological and immunological characterization of protein antigens, the creation of DNA vaccines, as well as high throughput technologies userful for identification of antibodies directed to non-immunogenic peptide antigens as well as biomarker discovery (scFv antibody arrays). Services include design of antigens, immunization and screening strategies; hybridoma cell line production and optimization; cloning, expression and engineering of single chain antibody variable fragments.

Location:
Fred Hutchinson Cancer Research Center

For additional information:
http://sharedresources.fhcrc.org/core-facilities/antibody-development

Biostatistics

The Biostatistics resource provides collaborative statistical support to Consortium members in any of the consortium research programs Such support may include any or all of the following: selection of primary and secondary endpoints, study design, sample size and power calculations, randomization procedures, design of data collection instruments, design of early stopping criteria, interim monitoring, data retrieval and analysis and manuscript preparation and review. The resource emphasizes the importance of establishing ongoing and continuing collaboration with biostatisticians during the entire research effort.

Location:
Fred Hutchinson Cancer Research Center

Resource Head:
Barry Storer, PhD

For additional information:
http://www.cancerconsortium.org/en/support/overview/biostatistics.html

Cellular Imaging

The Cellular Imaging Facility provides access to and training in high resolution, state of the art imaging technologies. These technologies are essential tools for studying the mechanisms of cancer at the molecular, cellular and organismal level. The resource is comprised of two service based laboratories, Electron Microscopy (EM) and Scientific Imaging (SI). The EM laboratory is a full service facility that offers sample preparation, microtomy, cryo and immuno EM technologies and training in both transmission and scanning electron microscopy. The SI laboratory provides advanced imaging systems for confocal, deconvolution and two photon fluorescence light microscopy, along with powerful software for visualization and quantitative analysis of microscopy data.

Location:
Fred Hutchinson Cancer Research Center

EM Manager:
Bobbie Schneider

SI Director:
Julio Vazquez, PhD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/electron-microscopy

http://sharedresources.fhcrc.org/core-facilities/scientific-imaging

Collaborative Data Services

Collaborative Data Services provides a broad range of specialized services to support the collection, storage and analysis of complex datasets. Services include sample development, interviewing, mailing and tracking of questionnaires, data entry, programming support, database management and respondent tracking.

Location:
Fred Hutchinson Cancer Research Center

Director:
Catherine Duggan PhD

Faculty Advisor:
Mary Ann Rossing DVM, PhD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/collaborative-data-services
 

Comparative Medicine

Comparative Medicine provides a broad variety of animal housing, veterinary and research support services. The facility is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) and complies with all United States Department of Agriculture (USDA), Public Health Service (PHS), Washington State and local area animal welfare regulations.

Location: 
Fred Hutchinson Cancer Research Center

Director: 
Rajesh K. Uthamanthil, DVM, Ph.D.

For additional information:
http://sharedresources.fhcrc.org/core-facilities/comparative-medicine

Computational Biology

The Computational Biology Resource will provide analysis of high throughput data on a genome-wide and/or proteome-wide basis. The resource will provide guidance in experimental design, preprocessing and quality assurance of data, choice of analysis methodology and consulting services on appropriate software tools for each of these steps. In addition, the core will have the responsibility of acquiring and integrating newly developed software platforms and tools to cope with the Consortium’s growing data types.

For additional information:
http://sharedresources.fhcrc.org/core-facilities/computational-biology

Consortium Biospecimen Resource

The Cancer Consortium Biospecimen Resource (CBR) was founded with the understanding that major biomedical advances in this country relating to detection, treatment, and prevention of solid tumor cancers have been achieved through access to biospecimens. To catalyze cancer research and biomarker discovery, the CBR will provide investigators with a comprehensive biospecimen collection and distribution system that meets the detailed requirements of their research protocols and all applicable human subjects regulations. When fully-implemented, two services will link investigators to high-quality, annotated human biospecimens:

Investigators will be able to search existing Consortium repositories for biospecimens that are potentially available for new research studies
The CBR will prospectively collect and distribute research tissue and/or blood specimens from surgeries and clinic procedures at Consortium facilities.

Development of the CBR is made possible by a grant from the Washington State Life Sciences Discovery Fund (LSDF) and institutional support from the partners of the Cancer Consortium: Fred Hutchinson Cancer Research Center, University of Washington (primarily through the Institute of Translational Health Sciences (ITHS)), Seattle Children’s (SC) and Seattle Cancer Care Alliance (SCCA).

Phone: (206) 667-5504
Email: brstein@fhcrc.org
Contact: Barbara Stein

For additional information: http://sharedresources.fhcrc.org/core-facilities/consortium-biospecimen-resource

Epidemiology

The Epidemiology resource supports the patient data access and consulting needs of investigators who conduct population based studies of the etiology, treatment, psychosocial sequelae and prognosis of cancer. The resource achieves this aim primarily by providing access to and scientific expertise about, population-based data on cancer diagnoses collected by the Cancer Surveillance System of western Washington (CSS). The resource provides the infrastructure to coordinate access to the CSS, to develop policies and procedures for use of its confidential patient information, and to implement informatics tools that enhance the ability of investigators to conduct research on population-based series of cancer patients.

Location:
Fred Hutchinson Cancer Research Center

Resource Head:
Stephen Schwartz, PhD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/epidemiology

Genomics

The Genomics Resource provides support and technical expertise to researchers with studies employing genomics-based methodologies. Services provided by the resource include capillary-based DNA sequencing and genotyping, high-throughput sequencing-by-synthesis (HT-SBS) technology and various applications employing microarray technology platforms.

Locations:
Fred Hutchinson Cancer Research Center
University of Washington

Director:
Jeff Delrow, PhD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/genomics

High Throughput Screening Facility

To provide scientists within the Consortium the ability to perform screens that address a range of topics, from control of mitosis to the discovery of novel antibodies to the basis for cell viability to identification of genes and proteins involved in human embryonic stem cell differential, the Consortium will develop a resource that will include sophisticated robotic systems to conduct high throughput screens of various types. The facility will provide an effective and accessible resource for all fields of biology and for all model systems.

Immune Monitoring

The Immune Monitoring Lab provides investigators with a broad spectrum of services and expertise to carry out a range of assays of human proteins and other biological mediators and perform studies where precise evaluations of the immunologic response are required. Resource services include the production of peptide-MHC Class-1 tetramers, unique reagents for accessing antigen-specific T cells; molecular assays for T cell receptor (TCR) related analysis, cellular assays for determining cellular function and analytical services using ELISA and Luminex microbead methodology.

Location:
Fred Hutchinson Cancer Research Center

Director:
Jianhong Cao, PhD

Faculty Advisors:
George McDonald, MD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/immune-monitoring

Nutrition Assessment

The Nutrition Assessment Shared Resource (NASR) provides state-of-the-art methods for collection and analysis of dietary intake data from participants in observational and intervention studies. This shared resource supports multiple standard approaches to dietary assessment, including 24-hour dietary recalls, multiple-day food records, food frequency questionnaires (FFQ) and modified dietary intake records (MDI). NASR also develops and validates new approaches to dietary assessment and analysis of dietary intake data.

Locations:
Fred Hutchinson Cancer Research Center
University of Washington

Director:
Carolyn Ehret

Faculty Advisor:
Alan Kristal, DrPH

For additional information:
http://sharedresources.fhcrc.org/core-facilities/nutrition-assessment

NWBioTrust

NWBioTrust (NWBT) is a collaborative Fred Hutchinson/University of Washington research resource dedicated to increasing the availability of high-quality, annotated human biospecimens that meet the detailed requirements of translational research and abide by all applicable human subjects regulations. NWBT connects donated tissue samples from consented patients to cutting-edge research studies in two ways:

1. NWBT maintains a catalog of banked biospecimens from participating repositories that are potentially available for new research studies.

2. NWBT provides a comprehensive biospecimen acquisition and distribution system for tissue and blood samples from surgery, pathology, out-patient clinics, and laboratory medicine.

Contact: Barbara Stein

Phone: (206) 667-5504

Email the NWbioTrust

For additional information:
https://www.nwbiotrust.org/en.html

Prevention Center

The Prevention Center serves a broad range of investigator-initiated inquiry into the causes, progression, control, treatment and prevention of disease. The resource supports clinical research investigations on normal and abnormal physiology. The Center functions as a full service research facility, provides training and certification for technical staff, and serves as a training facility for investigators, fellows and students. Very few research centers, especially cancer centers, in the country have the expertise or the capability of conducting controlled nutrition interventions.

Locations:
Fred Hutchinson Cancer Research Center
University of Washington

Director:
Anne McTiernan MD, PhD

Co-director:
Johanna Lampe PhD

Administrative Manager:
JoAnn Henderson, MPH

For additional information:
http://sharedresources.fhcrc.org/core-facilities/prevention-center

Proteomics

The Proteomics Shared Resource utilizes state of the art mass spectrometry instrumentation to support Consortium investigators. It is the mission of the resource to provide high quality service in a timely manner for proteomic analyses, including molecular weight determinations of proteins and peptides, protein identification and quantification, and protein modification characterization.

Location:
Fred Hutchinson Cancer Research Center

Director:
Phil Gafken PhD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/proteomics

Research Pathology

The Research Pathology resource is comprised of two service based laboratories.  The Experimental Histopathology lab provides special stains and immunohistology in addition to routine histology services.  The Specialized Pathology Section provides support for laser capture microdissection, tissue microarray and expert pathology review for solid tumor specimens from large research studies.

Location:  
Fred Hutchinson Cancer Research Center

Director, Experimental Histopathology: 
Julie Randolph-Habecker, PhD

Director, Specialized Pathology: 
Peggy Porter, MD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/experimental-histopathology

http://sharedresources.fhcrc.org/core-facilities/specialized-pathology

Specimen Processing

The Specimen Processing Resource provides dedicated laboratory support with a strong emphasis on quality control for large population based studies and clinical trials. The resource provides a broad range of services including the development of procedures for specimen processing and analyses; sample processing and DNA extraction.

Location:
Fred Hutchinson Cancer Research Center

Manager:
Jon Digel

For additional information:
http://sharedresources.fhcrc.org/core-facilities/specimen-processing

Therapeutic Manufacturing

The Therapeutic Manufacturing resource supports the development and manufacturing of novel biological molecules and innovative cell-based therapies for Phase I/II clinical testing. This resource allows the Consortium to build on it’s leadership role in the application of immunotherapy for the treatment of hematological malignancies, and to extend this innovative work to other clinical settings such as autoimmune disorders, melanoma, breast, ovary, and prostate cancer. These facilities permit the reproducible production of large-scale quantities of biological reagents and therapeutic cells under the strict quality control and safety conditions required by the FDA for human studies. Successful development of such materials will have obvious significance for many patients. Further, progress in pursuit of these aims will have relevance for other clinical situations, teaching us valuable lessons about the molecular basis for disease progression, induction of transplant tolerance, response to infectious diseases, and especially about immunotherapy approaches for the treatment of cancer.

Locations:
Fred Hutchinson Cancer Research Center
University of Washington Medical Center

Director of Manufacturing:
Ron Manger, PhD

Quality Assurance Director:
Catherine Lindgren

Scientific Advisor:
Shelly Heimfeld, PhD

Medical Director:
Michael Linenberger, MD

For additional information:
http://sharedresources.fhcrc.org/core-facilities/biologics-production

http://sharedresources.fhcrc.org/core-facilities/cell-processing

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